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Continuing education can compensate for dementia symptoms
Written by Taylor Burns   
Tuesday, 27 July 2010

Researchers have found that those with increased education are less likely to have displayed symptoms of the disease in their lifetime, suggesting increased schooling to have a compensatory effect on the brain.

Until now, the folk hypothesis regarding the link between education and dementia has assumed that an increase in the former acts as a buffer towards the latter, substantially lowering the risk of dementia diagnosis. But Cambridge and Finnish researchers, publishing their results in the most recent issue of Brain, have now demonstrated that education acts more as a coping mechanism for the disease, while also decreasing risk.

The international team examined the brains of almost 900 people who had been participants in ageing studies. Post-mortem analysis showed the pathology of the disease to be the same regardless of differing education levels. Yet differing education levels appeared to have a significant impact on whether the participants displayed symptoms of their pathology towards death.

It also confirmed the folk hypothesis, demonstrating that for each year spent in education there was an 11% decreased risk of developing dementia.

The task now, argue the authors, is for scientists to discover why this effect occurs, and for policy makers to rethink resource allocation in light of these new links between health and education.

 
The Passion and Profession of Richard Ernst
Written by Wing Ying Chow   
Tuesday, 20 July 2010
On Wednesday 7 July, an audience of over a thousand scientists gathered to hear Nobel laureate Richard Ernst talk about the scientific investigations on Tibetian religious paintings known as thangkas.

Richard Ernst is one of the forefathers of the analytical technique known as nuclear magnetic resonance (NMR). The Nobel Prize was awarded solely to him in 1991, "for his contributions to the development of the methodology of high resolution NMR spectroscopy." In this talk, he addressed an international community of magnetic resonance scientists whose work is based on the fundamentals laid by Ernst.

Since 1968, Ernst has had a passion for collecting Tibetan thangkas. In order to understand the chemical composition of their paint pigments in a completely non-invasive manner, he has had to utilise techniques beyond NMR.

Infra-red spectroscopy is one such technique. It allows you to can see through certain layers of coloured paint to the black ink underneath. The technique was applied to an 18th century painting that depicts the workshop of the master painter Zhu-chuen. The master painter initially outlined the thangka. Monks and lay painters then applied coloured pigments. To denote which areas were to be painted which colour, the master used single-letter codes, these have been revealed by the infra-red camera.



Another technique is Raman spectroscopy. This allows the chemical composition of the paint to be determined non-destructively and enables Nepalese and Tibetan paintings to be distinguished. Nepalese paintings contain a green colour, which is a mixture of indigo (blue) and orpiment (yellow) pigments, while Tibetan uses malachite which is a bright green pigment. One of the risks of using Raman spectroscopy is that holes can be burnt into the painting if the laser power is too high. While possibly horrifying museum conservators, he claims that the holes are so small that if he looks at another area and then returns, he can't find the holes again!



These investigations are carried out in his own home, where his collection of thangkas is housed in the rooms which used to be occupied by his children. His paintings and art give him a passion, which is driven by his professional interest in understanding aspects of the paintings scientifically. It was a very enjoyable and inspiring lecture given by one of the great scientists of our time.
 
Revolutionising life
Written by Taylor Burns   
Monday, 05 July 2010

Researchers have discovered 2.1 billion year-old fossils that answer new questions about the origins of life on Earth.

A mass fossil discovery in Gabon has provided proof of the existence of multicellular organisms 2.1 billion years ago, challenging established ideas about the transition from single- to multi-cell organisms. The finding, out of CNRS/Universite de Poitiers, is published in the most recent edition of Nature.

Initial Earthly life came in the form of single-celled prokaryotic organisms roughly three and a half billion years ago. Increased complexity ensued, with eukaryotes (single-celled structures which, unlike pokaryotes, contain a nucleus) developing approximately 2 billion years ago. There is however, little else known about the development of life in this embryonic phase, a period dubbed the Porterozoic era, dated from approximately 3.5 to 600 million years ago.

In Gabon, while digging in 2.1 billion-year-old sediment, the interdisciplinary French research team collected more than 250 fossils which, being 10 to 12 centimeters long, were too large and complex to be pokaryotes or eukaryotes.  They often collected the specimens in concentrated blocks across scattered terrain suggesting that the organisms lived in colonies in a shallow marine environment.

These findings constitute a milestone in understanding life's origins. Previously, the oldest complex life forms were dated from approximately 600 million years ago. The new discovery moves the timeline of complex life back 1.5 billion years, challenging previously held norms regarding organic diversity.

 
The Casanova antidote: how testosterone increases skepticism in women's perception of men
Written by Taylor Burns   
Wednesday, 30 June 2010

Dutch researchers have demonstrated that testosterone, which is suggested to have antagonistic properties to oxytocin, downgrades interpersonal trust and enhances cautious interaction between humans.

From Bernie Madoff to Tiger Woods, from Aeschylus to Shakespeare, many human scripts of tragedy and betrayal can be better understood in the context of oxytocin. Gestures of affection and compassion: a caress, promise or well-delivered financial commitment, will discharge oxytocin into the bloodstream. In 2005, Swiss researchers found that after individually delivering a squirt of oxytocin to subjects, the peptide hormone increased trust in an investment game, at once expanding both interaction and potential for betrayal.

Scientists at Utrecht University seem to have identified testosterone as the antidote to this excessive trust. They administered testosterone, in the form of a liquid drop under the tongue, to young women who were then asked to judge the trustworthiness of certain men's faces. Those under the influence of testosterone were significantly less likely to trust the faces.

Women already deemed to be less trusting, due to a natural inhibition to oxytocin in the placebo test, were hardly affected by the testosterone dosage, while the more trusting women had their attitudes change substantially. Testosterone thus seems to be, in the context of trustworthiness, a protective mechanism for women. It adaptively increases social vigilance and stigmatisation in trusting individuals to better protect their long-term interests.

This study comes on the heels of notable research into testosterone's effect on fair bargaining behaviour and the female libido. Folk wisdom has generalised findings from animal studies to conclude that testosterone is most likely responsible for increasing antisocial and aggressive human behaviour. While, research published in Nature in January demonstrates that a single dose of testosterone in women substantially reduces bargaining conflicts and increases the efficiency of social interactions. Testosterone is also known from other studies to enhance a woman's libido, as there is a peak production of the hormone in the period prior to ovulation.

Combined, this recent testosterone research demonstrates that, in women, high levels of the hormone elicits fair and efficient social behaviour, heightened skepticism about other individual's intentions, and increased sexual desire. From this, the Dutch researchers conclude that "the hormone seems to motivate for rational decision-making, social scrutiny and cleverness, the apparent tools for success in a modern society."

The research is published in the Proceedings of the National Acadamey of Science.

 
Natural selection in favour of specialisation
Written by Taylor Burns   
Monday, 21 June 2010

Despite outliving the Ice Age, the Hundsheim rhinoceros rapidly disappeared without any effective changes to its environment, becoming foe to two more specialised and less ecologically-diverse rhino species that monopolized the food supply in particular climates. German researchers at the Senckenberg Research Institute and the University of Hamburg have explained why, after almost a million years of survival through testing conditions, the Hundsheim rhinoceros (Stephanorhinus hundsheimensis) suddenly disappeared.

By examining the dental fossils of the rhino, the team were able to identify an extremely diverse dietary spectrum and tolerance to differing ecological conditions, allowing the species to survive harsh conditions, such as the Ice Age, by dominating forests and open plains.  Yet approximately half a million years ago, two new, highly specialised rhinoceros species developed during periods of extended cold and hot periods. The anatomical characteristics of these novel types (Stephanorhinus hemitoechus and Stephanorhinus kirchbergensis) suggest that they were better able to process and consume steppe and forest nutrition respectively, introducing unprecedented competition, with entirely different feeding strategies, for the Hundsheim rhino.

Despite being attributed with the broadest tolerance to vegetation of any known species, living or extinct, the study indicates that this non-specialised tolerance was fundamental to Hundsheim rhino's extinction, despite a generally benign (or even favourable) ecology and without interference by early humans.

The results are published in the Quaternary Science Reviews

 


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