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Continuing education can compensate for dementia symptoms
Written by Taylor Burns   
Tuesday, 27 July 2010

Researchers have found that those with increased education are less likely to have displayed symptoms of the disease in their lifetime, suggesting increased schooling to have a compensatory effect on the brain.

Until now, the folk hypothesis regarding the link between education and dementia has assumed that an increase in the former acts as a buffer towards the latter, substantially lowering the risk of dementia diagnosis. But Cambridge and Finnish researchers, publishing their results in the most recent issue of Brain, have now demonstrated that education acts more as a coping mechanism for the disease, while also decreasing risk.

The international team examined the brains of almost 900 people who had been participants in ageing studies. Post-mortem analysis showed the pathology of the disease to be the same regardless of differing education levels. Yet differing education levels appeared to have a significant impact on whether the participants displayed symptoms of their pathology towards death.

It also confirmed the folk hypothesis, demonstrating that for each year spent in education there was an 11% decreased risk of developing dementia.

The task now, argue the authors, is for scientists to discover why this effect occurs, and for policy makers to rethink resource allocation in light of these new links between health and education.

Read more...
 
The Passion and Profession of Richard Ernst
Written by Wing Ying Chow   
Tuesday, 20 July 2010
On Wednesday 7 July, an audience of over a thousand scientists gathered to hear Nobel laureate Richard Ernst talk about the scientific investigations on Tibetian religious paintings known as thangkas.

Richard Ernst is one of the forefathers of the analytical technique known as nuclear magnetic resonance (NMR). The Nobel Prize was awarded solely to him in 1991, "for his contributions to the development of the methodology of high resolution NMR spectroscopy." In this talk, he addressed an international community of magnetic resonance scientists whose work is based on the fundamentals laid by Ernst.

Since 1968, Ernst has had a passion for collecting Tibetan thangkas. In order to understand the chemical composition of their paint pigments in a completely non-invasive manner, he has had to utilise techniques beyond NMR.

Infra-red spectroscopy is one such technique. It allows you to can see through certain layers of coloured paint to the black ink underneath. The technique was applied to an 18th century painting that depicts the workshop of the master painter Zhu-chuen. The master painter initially outlined the thangka. Monks and lay painters then applied coloured pigments. To denote which areas were to be painted which colour, the master used single-letter codes, these have been revealed by the infra-red camera.



Another technique is Raman spectroscopy. This allows the chemical composition of the paint to be determined non-destructively and enables Nepalese and Tibetan paintings to be distinguished. Nepalese paintings contain a green colour, which is a mixture of indigo (blue) and orpiment (yellow) pigments, while Tibetan uses malachite which is a bright green pigment. One of the risks of using Raman spectroscopy is that holes can be burnt into the painting if the laser power is too high. While possibly horrifying museum conservators, he claims that the holes are so small that if he looks at another area and then returns, he can't find the holes again!



These investigations are carried out in his own home, where his collection of thangkas is housed in the rooms which used to be occupied by his children. His paintings and art give him a passion, which is driven by his professional interest in understanding aspects of the paintings scientifically. It was a very enjoyable and inspiring lecture given by one of the great scientists of our time.
 
Revolutionising life
Written by Taylor Burns   
Monday, 05 July 2010

Researchers have discovered 2.1 billion year-old fossils that answer new questions about the origins of life on Earth.

A mass fossil discovery in Gabon has provided proof of the existence of multicellular organisms 2.1 billion years ago, challenging established ideas about the transition from single- to multi-cell organisms. The finding, out of CNRS/Universite de Poitiers, is published in the most recent edition of Nature.

Initial Earthly life came in the form of single-celled prokaryotic organisms roughly three and a half billion years ago. Increased complexity ensued, with eukaryotes (single-celled structures which, unlike pokaryotes, contain a nucleus) developing approximately 2 billion years ago. There is however, little else known about the development of life in this embryonic phase, a period dubbed the Porterozoic era, dated from approximately 3.5 to 600 million years ago.

In Gabon, while digging in 2.1 billion-year-old sediment, the interdisciplinary French research team collected more than 250 fossils which, being 10 to 12 centimeters long, were too large and complex to be pokaryotes or eukaryotes.  They often collected the specimens in concentrated blocks across scattered terrain suggesting that the organisms lived in colonies in a shallow marine environment.

These findings constitute a milestone in understanding life's origins. Previously, the oldest complex life forms were dated from approximately 600 million years ago. The new discovery moves the timeline of complex life back 1.5 billion years, challenging previously held norms regarding organic diversity.

 
The Casanova antidote: how testosterone increases skepticism in women's perception of men
Written by Taylor Burns   
Wednesday, 30 June 2010

Dutch researchers have demonstrated that testosterone, which is suggested to have antagonistic properties to oxytocin, downgrades interpersonal trust and enhances cautious interaction between humans.

From Bernie Madoff to Tiger Woods, from Aeschylus to Shakespeare, many human scripts of tragedy and betrayal can be better understood in the context of oxytocin. Gestures of affection and compassion: a caress, promise or well-delivered financial commitment, will discharge oxytocin into the bloodstream. In 2005, Swiss researchers found that after individually delivering a squirt of oxytocin to subjects, the peptide hormone increased trust in an investment game, at once expanding both interaction and potential for betrayal.

Scientists at Utrecht University seem to have identified testosterone as the antidote to this excessive trust. They administered testosterone, in the form of a liquid drop under the tongue, to young women who were then asked to judge the trustworthiness of certain men's faces. Those under the influence of testosterone were significantly less likely to trust the faces.

Women already deemed to be less trusting, due to a natural inhibition to oxytocin in the placebo test, were hardly affected by the testosterone dosage, while the more trusting women had their attitudes change substantially. Testosterone thus seems to be, in the context of trustworthiness, a protective mechanism for women. It adaptively increases social vigilance and stigmatisation in trusting individuals to better protect their long-term interests.

This study comes on the heels of notable research into testosterone's effect on fair bargaining behaviour and the female libido. Folk wisdom has generalised findings from animal studies to conclude that testosterone is most likely responsible for increasing antisocial and aggressive human behaviour. While, research published in Nature in January demonstrates that a single dose of testosterone in women substantially reduces bargaining conflicts and increases the efficiency of social interactions. Testosterone is also known from other studies to enhance a woman's libido, as there is a peak production of the hormone in the period prior to ovulation.

Combined, this recent testosterone research demonstrates that, in women, high levels of the hormone elicits fair and efficient social behaviour, heightened skepticism about other individual's intentions, and increased sexual desire. From this, the Dutch researchers conclude that "the hormone seems to motivate for rational decision-making, social scrutiny and cleverness, the apparent tools for success in a modern society."

The research is published in the Proceedings of the National Acadamey of Science.

 
Pigeons carry harmful pathogens
Written by Nitika Somani   
Tuesday, 29 June 2010

Feral pigeons could be asymptomatic or subclinical carriers of the pathogens Chlamydophila psittaci and Campylobacter jejuni, responsible for acute diarrhea in humans.

The scientists tested a total of 118 pigeons, captured using gun-propelled nets during 2006-2007, from the public parks and gardens in Madrid, Spain. Blood and enema samples were analysed and screened for the presence of pathogens. DNA sequencing was carried out for positive samples. A high prevalence of Chlamydophila psittaci (52.6%) and Campylobacter jejuni (69.1%) was seen in the captured birds. The birds themselves did not have exhibit any of the symptoms associated with being infected with these pathogens. This suggests that feral pigeons act as asymptomatic reservoirs of Chlamydophila psittaci and Campylobacter jejuni.

Although there have been few reports of disease transmission between pigeons and humans, it can occur by aerosols, direct contact or indirect contact through food and water contamination. Given the high density of pigeons in the public parks and gardens of most cities, it poses a direct threat to public health.

The results are published in the open access journal Acta Vetinaria Scandinavica.

 
Natural selection in favour of specialisation
Written by Taylor Burns   
Monday, 21 June 2010

Despite outliving the Ice Age, the Hundsheim rhinoceros rapidly disappeared without any effective changes to its environment, becoming foe to two more specialised and less ecologically-diverse rhino species that monopolized the food supply in particular climates. German researchers at the Senckenberg Research Institute and the University of Hamburg have explained why, after almost a million years of survival through testing conditions, the Hundsheim rhinoceros (Stephanorhinus hundsheimensis) suddenly disappeared.

By examining the dental fossils of the rhino, the team were able to identify an extremely diverse dietary spectrum and tolerance to differing ecological conditions, allowing the species to survive harsh conditions, such as the Ice Age, by dominating forests and open plains.  Yet approximately half a million years ago, two new, highly specialised rhinoceros species developed during periods of extended cold and hot periods. The anatomical characteristics of these novel types (Stephanorhinus hemitoechus and Stephanorhinus kirchbergensis) suggest that they were better able to process and consume steppe and forest nutrition respectively, introducing unprecedented competition, with entirely different feeding strategies, for the Hundsheim rhino.

Despite being attributed with the broadest tolerance to vegetation of any known species, living or extinct, the study indicates that this non-specialised tolerance was fundamental to Hundsheim rhino's extinction, despite a generally benign (or even favourable) ecology and without interference by early humans.

The results are published in the Quaternary Science Reviews

 
Brain's Expectations
Written by Ayesha Sengupta   
Monday, 21 June 2010

A damaged prefrontal cortex leads to impaired preparation and reaction speeds in response to a stimulus.

The brain's right prefrontal cortex is responsible for anticipation and quick reactions to stimuli. This is involved in preparing for an event before it actually occurs. Research at the University of Granada has investigated the impact of damage to the frontal cortex on responses to stimuli. The aspects considered were temporal preparation, the interval between the stimulus and the response and sequential effects on the reaction.

The subjects were in three groups: those with damage to the prefrontal cortex, those with damage to the left frontal cortex and basal ganglia circuits and as a control, the healthy individuals. They were shown a sign that both validly and invalidly predicted a stimulus. It was valid when the stimulus followed directly afterwards, but was invalid when it was presented either too early or too late and had little predicting power. This sign was used to test the patients' anticipation.

While the subjects with damage to the prefrontal cortex demonstrated a deficiency in temporal preparation, both of the other groups showed normal preparation. The same result was obtained with regard to the stimulus-response interval; only the group with damage to the prefrontal cortex demonstrated impaired preparation effects. However, normal sequential reactions were conserved in all of the groups.

The study has shown that damage to the right prefrontal cortex impairs intentional anticipation, but unintentional anticipation continues to function. This could give rise to forms of therapy, and the researchers are currently looking into this. They are investigating the dependency of a patient's response speed on intentional anticipation. They hope that providing rhythms, which appeals to unintentional preparation, can improve the patient's temporal preparation.

The results are published in the journal Brain.

 
Life on Mars? New evidence reinvigorates old questions.
Written by Taylor Burns   
Friday, 18 June 2010

High-levels of carbonate minerals suggest a more favourable environment for life in the Red Planet's past.

Findings from 'Spirit', one of NASA's Mars Rovers, hints at a warm, wet climate on Mars some four billion years ago. This hypothesis, although first postulated decades ago, has now been lent credence by dedicated analysis of the Rover's spectrometer data over a period of several years. The international research team lead by Richard Morris of the NASA Johnson Space Center have published their results in Science.

Conditions ideal for life could only have been present if Mars had previously contained a significant volume of water (with a relatively neutral pH) and higher levels of carbon in an altogether warm, moist and dense atmosphere. Perhaps the best evidence for this previously carbon-dense environment would be rock formations with high carbonate mineral content, as such outcrops could only occur in moist climates, while the aqueous processes of carbonate formation in rocks would further suggest pH neutrality.

After analyzing the Mossbauer spectrometer on the Rover and corroborating these findings with further evidence from an alpha particle X-ray spectrometer and a thermal emission spectrometer, the researchers discovered that a rocky outcrop, called 'Comanche', contains a considerable amount of carbonates. The rocks, which consist of approximately 20 percent carbonates, are mostly composed of magnesium iron carbonate and their formation indicates an environment hospitable to life. Previously, the discovery of acidic surface waters on Mars was interpreted to suggest the implausibility of such an environment.

The study parallels the 1990's discovery of carbonate content in the Mars meteorite, dubbed ALH84001, that landed in Antarctica in 1986. Conclusions similar to the Comanche findings were drawn regarding a moist, carbon-rich environment with near neutral pH, implying traces of biological potentiality. It also coincides with a study published this week in Nature Geoscience, which suggests that an analysis of Martian delta deposits and distribution, combined with previous topographic analyses of the planet, indicates a vast ocean covering the northern hemisphere of Mars around 3.5 billion years ago.

 
Scientists create artificial mini black hole
Written by Nitika Somani   
Monday, 14 June 2010

Chinese researchers at the Southeast University in Nanjing have successfully built an electromagnetic absorbing device for microwave frequencies. They have utilised the special properties of metamaterials- a class of ordered composites which can distort light and other waves.

The device, officially called an 'omnidirectional electromagnetic absorber', consists of a thin cylinder containing 60 strips of circuit board arranged in concentric layers and  coated in copper.  Each layer is imprinted with alternating patterns, which either resonate or do not resonate with electromagnetic waves. The device can trap and absorb electromagnetic waves coming from all directions by spiraling the radiation inwards and converting its energy into heat with an absorption rate of 99%. Hence it behaves like an 'electromagnetic black body' or an 'electromagnetic black hole' and has been compared to an astrophysical black hole (which, soaks up matter and light).

This experimental result is in agreement with the theoretical work proposed  in 2009, where theoretical analysis and numerical simulations showed that all optical waves hitting the non-magnetic metamaterials are trapped and absorbed. This device at present only works at microwave frequencies, but the researchers are planning to develop a black hole for visible light next.

 
Reef restoration: cheap and simple solutions
Written by Imogen Ogilvie   
Sunday, 13 June 2010

Researchers from the University of Rhode Island have found that coral reef conservation can be achieved successfully through transplantation of fragmented corals. 

Asexual reproduction by fragmentation is the most common form of reproduction in natural populations of Elkhorn corals. Branches break off due to for example wave action in storms and some branches establish on the reef and grow. The decline of Elkhorn coral (Acropora palmata) is due mainly to white-band disease whose effects have been compounded by indirect human impacts such as coral bleaching.

Forrester and colleagues measured growth rates of Elkhorn corals, found growing in the Virgin Islands of Caribbean, under various different treatments. Their research, published in Restoration Ecology, shows a significant increase in growth rate and survival of attached coral fragments compared to unattached fragments. Removing macroalgae from around the attached fragments also increases the coral growth rate.  The method of attaching coral did not have an effect on coral growth although some methods may be more beneficial than others due to cost and efficiency constraints.

Coral restoration projects are rarely studied scientifically, but this research highlights that successful solutions are sometimes cheap and simple. Transplantation methods highlighted in the study can be undertaken by relatively untrained volunteers such as recreational divers. Further work to increase public education on conservation would also help to preserve these fragile and beautiful ecosystems.

 
Call for citizen scientists
Written by Wing Ying Chow   
Monday, 07 June 2010

An international team with researchers from the UK, Australia and China consider how our views of biodiversity can be distorted by the data we look at.

With 2010 being the Year of Biodiversity, the question of how to measure the current state of biodiversity and monitor changes is particularly relevant. To understand how different sources contribute to our understanding of the range and occurrence of a species, a team of 18 researchers undertook a systematic review of the Galliformes, which includes turkeys, chickens, quails, partridges and pheasants. As a group, these birds have an unusually good historical record as they have been hunted for their meat and their feathers are decorative and have cultural importance.

The sources of information on these birds include museums, the published literature, ringing (capture and release), ornithological atlases and trip reports on websites. While museums and literature provide the most detailed information of when and where a species has been recorded, they are not without bias. Both museum and literature data shows clustering in areas that have been studied more intensively and recent literature is biased towards reporting endangered species, which means that changes in the biodiveristy of other species may go unnoticed.

Access to the biodiversity information is also an issue. This is where citizen science projects could come in useful. Initiatives such as the eBird project (http://ebird.org/), allow users to report sightings of birds online making the data easily accessible. There are also attempts to highlight regions with few reports, to alleviate the geographical clustering problem and projects that record less 'charismatic' or popular organisms, such as freshwater sponges and lichens.

In line with their recommendations, the authors have published their study in the open access journal PLoS Biology. It is hoped that with the participation of citizens over the world, we can build up a comprehensive picture of how biodiversity changes over time and act together to tackle  and reverse the environmental issues that face humans and other organisms on Earth.

 
Disease resistance; not always a bonus.
Written by Nitika Somani   
Thursday, 03 June 2010

Scientists from the Max Planck Institute of Developmental Biology in Germany have explained an evolutionary dilemma in nature.  Plants, which are resistant to pathogens, grow more slowly and are less competitive than their susceptible relatives when enemies are rare or absent.

The group of Detlef Weigel studied mouse ear cress (Arabidopsis thaliana), which grows in areas from North Africa to Scandinavia and from Central Asia to Western Europe. They tracked down a variant of the ACD6 gene, which functions as a universal weapon in the fight against predators. With it, the plants produce more of a chemical that is directly toxic to microbes and more signaling molecules important in immunity. However, this gene also slows down the production of leaves and limits the size of leaves, so that these plants are always smaller than those that do not have this variant. Smaller size eventually leads to reduced number of seeds and hence to fewer progeny.

If they are attacked, the plants with the special ACD6 variant have a leg up compared to plants with the standard version. But at places or in years where there are few enemies, they are penalised and lose out compared to their larger fellow plants. The resistant variant is found in all areas where the mouse ear cress grows, but as a result of the disadvantage if confers, is only found in about 20 percent of individuals.

In the course of plant evolution, the dilemma of whether to invest into disease resistance or biomass seems to be dependent on the unpredictable circumstances a plant finds itself in. This explains why large, but vulnerable plants co-exist in nature with small, but well-protected ones.

www.nature.com

 
Bold geese trust themselves
Written by Wing Ying Chow   
Tuesday, 01 June 2010

A team of researchers from the Netherlands have fround that the personality of barnacle geese can affect how they use social information.

As many dog owners attest, animals have a personality. Ecologists define animal personality as a behaviour that is consistent over time and in different contexts. In this study, 'boldness' was measured by how individual geese reacted to novel objects, such as a piece of carpet, placed near to them,. Individuals that walked close to the object were characterised as bold, 'willing to take risks'. Geese that stayed away, on the other hand, were defined as 'shy'.

To find out whether and how barnacle geese use social information, the research team set up an experiment whereby all of the bold geese and the shy geese were given a 90 seconds to watch two groups of barnacle geese. One group of geese was given food, the other group was not. The behaviour of these two groups differed according to whether or not they were given food.

After watching the two groups, each goose was allowed to decide which group it wanted to join. Food was only made available to the geese on the side where the geese it had watched had been given food. They found that the shy geese were more likely to join the group that was eating. Bold individuals, on the other hand, ignored the social inofrmation and went searching for their own food.

In a follow-up experiment, the researchers tested whether the shy geese would continue to use the information even if it proved to be incorrect. Again there were two groups, one with food, the other without. However, this time the food for the geese watching was placed on the side where the geese had not been fed. They found that initially the shy geese were more likely to join the group that had been eating, but after six days of being presented with the incorrect setup they seem to be able to learn to ignore social information when choosing a group.

Most models of animal distribution assume that each individual uses social information to the same extent. This study shows that this is not the case, with animal personality playing an important part in the decision to disperse or congregate. Ideally, future models will include a range of animal personalities, which can be important for modelling the distribution of endangered species.

http://www3.interscience.wiley.com/journal/118545752/home

 
How nature's colours could cut bank fraud
Written by Katherine Thomas   
Monday, 31 May 2010

Scientists have discovered a way of mimicking the stunningly bright and beautiful colours found on the wings of tropical butterflies. The findings could have important applications in the security printing industry, helping to make bank notes and credit cards harder to forge.

Mathias Kolle, working with Prof. Ullrich Steiner and Prof. Jeremy Baumberg at the University of Cambridge, studied the Indonesian Peacock or Swallowtail butterfly (Papilio blumei), whose wing scales are composed of intricate, microscopic structures that resemble the inside of an egg carton.

The striking iridescent colours displayed on beetles, butterflies and other insects have long fascinated both physicists and biologists, but mimicking nature's most colourful, eye-catching surfaces has proved elusive. This is partly because rather than relying on pigments, these colours are produced by light bouncing off microscopic structures on the insects' wings.

Using a combination of nanofabrication procedures - including self-assembly and atomic layer deposition - Kolle and his colleagues made structurally identical copies of the butterfly scales, which produce the same vivid colours as the butterflies' wings. According to Kolle: "We have unlocked one of nature's secrets and combined this knowledge with state-of-the-art nanofabrication to mimic the intricate optical designs found in nature."

"Although nature is better at self-assembly than we are, we have the advantage that we can use a wider variety of artificial, custom-made materials to optimise our optical structures."

As well as helping scientists gain a deeper understanding of the physics behind these butterflies' colours, being able to mimic them has promising potential applications in security printing.

"These artificial structures could be used to encrypt information in optical signatures on banknotes or other valuable items to make protect them against forgery. We still need to refine our system but in future we could see structures based on butterflies wings shining from a ten-pound note or even our passports," he says.

Intriguingly, the butterfly may also be using its colours to encrypt itself - appearing one colour to potential mates but another colour to predators.

Kolle explains: "The shiny green patches on this tropical butterfly's wing scales are a stunning example of nature's ingenuity in optical design. Seen with the right optical equipment these patches appear bright blue, but with the naked eye they appear green. This could explain why the butterfly has evolved this way of producing colour. If its eyes see fellow butterflies as bright blue, while predators only see green patches in a green tropical environment, then it can hide from predators at the same time as remaining visible to members of its own species."

The results are published in Nature Nanotechnology.

 
The little things count
Written by Wing Ying Chow   
Thursday, 27 May 2010

Psychologists in California and North Carolina have conducted an in-depth study into how the emotion of gratitude can boost romantic relationships.

When someone does something thoughtful for you, do you feel grateful, or do you feel indebted? What about when that person is your significant other? There is a hypothesis that while gratitude inspires creative repayments and enhances relationships, felling indebt to someone only motivates a dutiful 'exchange' of benefits.

Algoe, Gable and Maisel looked at the interplay between these emotions and the effect on romantic relationships. A group of sixty-seven cohabiting couples, completed a brief questionnaire every evening for a fortnight. They were asked about whether they had done something thoughtful for their partner and whether they thought their partner had done something thoughtful for them. The results show that on average each participant only noticed that their partners had done something thoughtful for them half of the time (51%).

The perception of thoughtful acts were seen to have subtly different effects depending on gender; the men felt indebted and grateful, while the women simply felt grateful. The feeling of gratitude was found to be linked to higher satisfaction with the relationship and for men, a stronger feeling of connection with their partners. The analysis also showed that feeling indebt to your partner does not have the same enhancing effects on the relationship.

Compared to non-romantic relationships, the feeling of gratitude does not seem to enhance the relationship from day to day, only on the day the act was carried out and noticed. The researchers believe that this is because romantic relationships are already very close, with various mutually beneficial arrangements in place. The researchers concluded that even in strong, ongoing romantic relationships, there is still a place for gratitude, which can boost the quality of the relationship and possibly turn 'ordinary moments' into opportunities for relationship growth.

 
Important enzyme for TB found
Written by Nitika Somani   
Monday, 24 May 2010

Researchers from the USA and Singapore have demonstrated that the enzyme PEPCK (phosphoenolpyruvate carboxykinase), plays a pivotal role in the growth and survival of Mycobacterium tuberculosis (Mtb) during infections in mice.

A defining feature of the pathogenicity of Mtb, is metabolic adaptation to the host. In vitro, Mtb is able to grow on a variety of carbon sources, but mounting evidence implicates fatty acids as the major source of carbon and energy for Mtb during infection.

The researchers applied genetic analysis and carbon tracing to look at what role PEPCK may play. PEPCK is an important enzyme for Gluconeogenesis, the production of sugars from fatty acids, in Mtb growth and survival. They silenced the gene that codes for PEPCK in one Mtb strain and compared the growth of PEPCK-deficient bacteria with that of bacteria from an unmodified Mtb. They found that PEPCK is required for growth of Mtb both in vitro and in vivo. Importantly, Mtb which lacks PEPCK not only failed to replicate in mouse lungs but also failed to survive. Their results show that Mtb relies on Gluconeogenesis throughout the infection.

The experiments suggest that Mtb, the pathogenic bacterium responsible for most human tuberculosis cases, may use fatty acids for growth in vivo and points to PEPCK as potential target for anti-TB chemotherapy.

www.pnas.org

 


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